HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2

Histone deacetylase inhibitors (HDACi) comprise a family of chemotherapeutic agents used in the clinic to treat cutaneous T-cell lymphoma and tested for the therapy of other malignancies. Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi. However the kinase...

Descripción completa

Detalles Bibliográficos
Autores principales: Peidis, Philippos, Papadakis, Andreas I., Rajesh, Kamindla, Koromilas, Antonis E.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993797/
https://www.ncbi.nlm.nih.gov/pubmed/21076179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993797/
https://www.ncbi.nlm.nih.gov/pubmed/21076179

Ejemplares similares