Cargando…

HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2

Histone deacetylase inhibitors (HDACi) comprise a family of chemotherapeutic agents used in the clinic to treat cutaneous T-cell lymphoma and tested for the therapy of other malignancies. Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi. However the kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peidis, Philippos, Papadakis, Andreas I., Rajesh, Kamindla, Koromilas, Antonis E.
Formato:	Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993797/ https://www.ncbi.nlm.nih.gov/pubmed/21076179

Ejemplares similares

eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies
por: Rajesh, Kamindla, et al.
Publicado: (2013)

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
por: Krishnamoorthy, Jothilatha, et al.
Publicado: (2014)

Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency
por: Muaddi, Hala, et al.
Publicado: (2010)

The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress
por: Rajesh, Kamindla, et al.
Publicado: (2016)

The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells
por: Kusio-Kobialka, Monika, et al.
Publicado: (2012)

Involvement of the eIF2α Kinase GCN2 in UV-B Responses
por: Llabata, Paula, et al.
Publicado: (2019)

Arabidopsis eIF2α kinase GCN2 is essential for growth in stress conditions and is activated by wounding
por: Lageix, Sébastien, et al.
Publicado: (2008)

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2
por: Baker, Brooke M., et al.
Publicado: (2012)

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway
por: Tang, Yan, et al.
Publicado: (2017)

Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
por: Anderson, Bart R., et al.
Publicado: (2012)

Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
por: Devi, Latha, et al.
Publicado: (2013)

The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity
por: Stonyte, Vilte, et al.
Publicado: (2023)

Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells
por: Lageix, Sebastien, et al.
Publicado: (2014)

Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress
por: Rajesh, K, et al.
Publicado: (2015)

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
por: Cordova, Ricardo A, et al.
Publicado: (2022)

Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus
por: Zhang, Shilei, et al.
Publicado: (2014)

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
por: Zaborske, John M, et al.
Publicado: (2010)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer
por: He, Yong, et al.
Publicado: (2011)

A GCN2-Like eIF2α Kinase (LdeK1) of Leishmania donovani and Its Possible Role in Stress Response
por: Rao, Shilpa J., et al.
Publicado: (2016)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation
por: Ikegami, Tetsuro, et al.
Publicado: (2009)

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
por: Augusto, Leonardo, et al.
Publicado: (2019)

Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes
por: Bettaieb, Ahmed, et al.
Publicado: (2012)

Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway
por: Romero, Antonia María, et al.
Publicado: (2020)

Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2α Signaling Pathway in Triple Negative Breast Cancer
por: Li, Chen, et al.
Publicado: (2022)

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
por: Wuerth, Jennifer Deborah, et al.
Publicado: (2020)

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
por: Fritzlar, Svenja, et al.
Publicado: (2019)

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes
por: Podszywalow-Bartnicka, Paulina, et al.
Publicado: (2016)

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy
por: Darini, Cedric, et al.
Publicado: (2019)

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway
por: Carraro, Valérie, et al.
Publicado: (2010)

ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling
por: Yang, Shao-Ying, et al.
Publicado: (2023)

PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells
por: Ozpolat, Bulent, et al.
Publicado: (2012)

Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis
por: Zhu, Yujie, et al.
Publicado: (2023)

PKR: A Kinase to Remember
por: Gal-Ben-Ari, Shunit, et al.
Publicado: (2019)

eIF2α Phosphorylation by GCN2 Is Induced in the Presence of Chitin and Plays an Important Role in Plant Defense against B. cinerea Infection
por: Berrocal-Lobo, Marta, et al.
Publicado: (2020)

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
por: Parameswaran, Janani, et al.
Publicado: (2023)

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells
por: Krishnamoorthy, Jothilatha, et al.
Publicado: (2018)

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B
por: Kim, Eunah, et al.
Publicado: (2018)

A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α
por: Silva, Richard C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ggifgseckhqtotttgpkdbmtu1s