The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell adaptation to low oxygen and stabilization of HIF-1 is vital to ensure cell survival under hypoxia. Diabetes has been associated with impairment of the cell response to hypoxia and downregulation of HIF-1 is most likely the event that trans...

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Detalles Bibliográficos
Autores principales: Bento, Carla Figueira, Fernandes, Rosa, Ramalho, José, Marques, Carla, Shang, Fu, Taylor, Allen, Pereira, Paulo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993942/
https://www.ncbi.nlm.nih.gov/pubmed/21124777
http://dx.doi.org/10.1371/journal.pone.0015062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993942/
https://www.ncbi.nlm.nih.gov/pubmed/21124777
http://dx.doi.org/10.1371/journal.pone.0015062

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