Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo

AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our previous work showed the importance of activated AKT in mediating resistance of non-small cell lung cancer (NSCLC) to AZD6244. Thus we hypothesi...

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Detalles Bibliográficos
Autores principales: Meng, Jieru, Dai, Bingbing, Fang, Bingliang, Bekele, B. Nebiyou, Bornmann, William G., Sun, Duoli, Peng, Zhenghong, Herbst, Roy S., Papadimitrakopoulou, Vassiliki, Minna, John D., Peyton, Michael, Roth, Jack A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993951/
https://www.ncbi.nlm.nih.gov/pubmed/21124782
http://dx.doi.org/10.1371/journal.pone.0014124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993951/
https://www.ncbi.nlm.nih.gov/pubmed/21124782
http://dx.doi.org/10.1371/journal.pone.0014124

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