Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide

BACKGROUND: Poly(ADP-ribose) is a NAD(+)-requiring, DNA-repairing, enzyme playing a central role in pancreatic β-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation is also relevant to the development of complications of diabetes. Hence, a...

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Detalles Bibliográficos
Autores principales: Pandya, Kashyap G, Patel, Maulik R, Lau-Cam, Cesar A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994389/
https://www.ncbi.nlm.nih.gov/pubmed/20804590
http://dx.doi.org/10.1186/1423-0127-17-S1-S16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994389/
https://www.ncbi.nlm.nih.gov/pubmed/20804590
http://dx.doi.org/10.1186/1423-0127-17-S1-S16

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