Screening of Human Tumor Antigens for CD4(+) T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries

BACKGROUND: As tumor antigen-specific CD4(+) T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4(+) T cell epitopes suitable for detection, isolation and expansion of...

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Detalles Bibliográficos
Autores principales: Osen, Wolfram, Soltek, Sabine, Song, Mingxia, Leuchs, Barbara, Steitz, Julia, Tüting, Thomas, Eichmüller, Stefan B., Nguyen, Xuan-Duc, Schadendorf, Dirk, Paschen, Annette
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994730/
https://www.ncbi.nlm.nih.gov/pubmed/21152437
http://dx.doi.org/10.1371/journal.pone.0014137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994730/
https://www.ncbi.nlm.nih.gov/pubmed/21152437
http://dx.doi.org/10.1371/journal.pone.0014137

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