Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers

BACKGROUND: The non-receptor tyrosine kinases c-Abl and c-Src are overexpressed in various solid human tumours. Inhibition of their hyperactivity represents a molecular rationale in the combat of cancerous diseases. Here we examined the effects of a new family of pyrazolo [3,4-d] pyrimidines on a pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Kruewel, Thomas, Schenone, Silvia, Radi, Marco, Maga, Giovanni, Rohrbeck, Astrid, Botta, Maurizio, Borlak, Juergen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994747/
https://www.ncbi.nlm.nih.gov/pubmed/21152443
http://dx.doi.org/10.1371/journal.pone.0014143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994747/
https://www.ncbi.nlm.nih.gov/pubmed/21152443
http://dx.doi.org/10.1371/journal.pone.0014143

Ejemplares similares