Diazeniumdiolate Mediated Nitrosative Stress Alters Nitric Oxide Homeostasis through Intracellular Calcium and S-Glutathionylation of Nitric Oxide Synthetase

BACKGROUND: PABA/NO is a diazeniumdiolate that acts as a direct nitrogen monoxide (NO) donor and is in development as an anticancer drug. Its mechanism of action and effect on cells is not yet fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We used HPLC and mass spectrometry to identify a primary...

Descripción completa

Detalles Bibliográficos
Autores principales: Manevich, Yefim, Townsend, Danyelle M., Hutchens, Steven, Tew, Kenneth D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994766/
https://www.ncbi.nlm.nih.gov/pubmed/21152397
http://dx.doi.org/10.1371/journal.pone.0014151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994766/
https://www.ncbi.nlm.nih.gov/pubmed/21152397
http://dx.doi.org/10.1371/journal.pone.0014151

Ejemplares similares