Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

The 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) enzymes catalyze sequential metabolic reactions in the folate biosynthetic pathway of bacteria and lower eukaryotes. Both enzymes represent validated targets for the development of novel anti-microbial...

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Detalles Bibliográficos
Autores principales: Pemble, Charles W., Mehta, Perdeep K., Mehra, Smriti, Li, Zhenmei, Nourse, Amanda, Lee, Richard E., White, Stephen W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994781/
https://www.ncbi.nlm.nih.gov/pubmed/21152407
http://dx.doi.org/10.1371/journal.pone.0014165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994781/
https://www.ncbi.nlm.nih.gov/pubmed/21152407
http://dx.doi.org/10.1371/journal.pone.0014165

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