Cargando…
IL-2 as a therapeutic target for the restoration of Foxp3(+ )regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
Peripheral immune tolerance requires a finely controlled balance between tolerance to self-antigens and protective immunity against enteric and invading pathogens. Self-reactive T cells sometimes escape thymic clonal deletion, and can subsequently provoke autoimmune diseases such as type 1 diabetes...
Autores principales: | d'Hennezel, Eva, Kornete, Mara, Piccirillo, Ciriaco A |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994816/ https://www.ncbi.nlm.nih.gov/pubmed/21059266 http://dx.doi.org/10.1186/1479-5876-8-113 |
Ejemplares similares
-
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3(+) Regulatory T Cells
por: Bin Dhuban, Khalid, et al.
Publicado: (2019) -
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance
por: Kornete, Mara, et al.
Publicado: (2012) -
Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
por: Kornete, Mara, et al.
Publicado: (2013) -
Th1-Like ICOS(+) Foxp3(+) T(reg) Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice
por: Kornete, Mara, et al.
Publicado: (2015) -
An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following Influenza A H1N1 infection
por: Lafferty, Erin I, et al.
Publicado: (2014)