Codon Preference Optimization Increases Heterologous PEDF Expression

Pigment epithelium-derived factor (PEDF) is widely known for its neurotrophic and antiangiogenic functions. Efficacy studies of PEDF in animal models are limited because of poor heterologous protein yields. Here, we redesigned the human PEDF gene to preferentially match codon frequencies of E coli w...

Descripción completa

Detalles Bibliográficos
Autores principales: Gvritishvili, Anzor G., Leung, Kar Wah, Tombran-Tink, Joyce
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994832/
https://www.ncbi.nlm.nih.gov/pubmed/21152082
http://dx.doi.org/10.1371/journal.pone.0015056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994832/
https://www.ncbi.nlm.nih.gov/pubmed/21152082
http://dx.doi.org/10.1371/journal.pone.0015056

Ejemplares similares