pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long...

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Detalles Bibliográficos
Autores principales: Williams, Timothy K., Costantino, Christina L., Bildzukewicz, Nikolai A., Richards, Nathan G., Rittenhouse, David W., Einstein, Lisa, Cozzitorto, Joseph A., Keen, Judith C., Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E., Yeo, Charles J., Witkiewicz, Agnieszka K., Brody, Jonathan R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994932/
https://www.ncbi.nlm.nih.gov/pubmed/21152064
http://dx.doi.org/10.1371/journal.pone.0015455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994932/
https://www.ncbi.nlm.nih.gov/pubmed/21152064
http://dx.doi.org/10.1371/journal.pone.0015455

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