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PARP1 suppresses homologous recombination events in mice in vivo

Recent studies suggest that PARP1 inhibitors, several of which are currently in clinical trial, may selectively kill BRCA1/2 mutant cancers cells. It is thought that the success of this therapy is based on immitigable lethal DNA damage in the cancer cells resultant from the concurrent loss or inhibi...

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Detalles Bibliográficos
Autores principales: Claybon, Alison, Karia, Bijal, Bruce, Crystal, Bishop, Alexander J. R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995050/
https://www.ncbi.nlm.nih.gov/pubmed/20660013
http://dx.doi.org/10.1093/nar/gkq624