Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents

Though medicines that target mRNA are under active investigation, there has been little or no effort to develop mRNA itself as a medicine. Here, we report the synthesis of a 130-nt mRNA sequence encoding a 33-amino-acid peptide that includes the sequence of glucagon-like peptide-1, a peptide that st...

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Detalles Bibliográficos
Autores principales: Nagata, Seigo, Hamasaki, Tomohiro, Uetake, Koichi, Masuda, Hirofumi, Takagaki, Kazuchika, Oka, Natsuhisa, Wada, Takeshi, Ohgi, Tadaaki, Yano, Junichi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995060/
https://www.ncbi.nlm.nih.gov/pubmed/20660478
http://dx.doi.org/10.1093/nar/gkq638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995060/
https://www.ncbi.nlm.nih.gov/pubmed/20660478
http://dx.doi.org/10.1093/nar/gkq638

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