Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M(1)dG

The biological aldehydes, malondialdehyde and base propenal, react with DNA to form a prevalent guanine adduct, M(1)dG. The exocyclic ring of M(1)dG opens to the acyclic N(2)-OPdG structure when paired with C but remains closed in single-stranded DNA or when mispaired with T. M(1)dG is a target of n...

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Detalles Bibliográficos
Autores principales: Cline, Susan D., Lodeiro, M. Fernanda, Marnett, Lawrence J., Cameron, Craig E., Arnold, Jamie J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995074/
https://www.ncbi.nlm.nih.gov/pubmed/20671026
http://dx.doi.org/10.1093/nar/gkq656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995074/
https://www.ncbi.nlm.nih.gov/pubmed/20671026
http://dx.doi.org/10.1093/nar/gkq656

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