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A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function
DNA topoisomerases manage chromosome supercoiling and organization in all forms of life. Gyrase, a prokaryotic heterotetrameric type IIA topo, introduces negative supercoils into DNA by an ATP-dependent strand passage mechanism. All gyrase orthologs rely on a homologous set of catalytic domains for...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995079/ https://www.ncbi.nlm.nih.gov/pubmed/20675723 http://dx.doi.org/10.1093/nar/gkq665 |