Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example

Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations have real effects in the protein’s function is not trivial. Protein design tools are commonly used to explain mutations that affect protein sta...

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Detalles Bibliográficos
Autores principales: Alibés, Andreu, Nadra, Alejandro D., De Masi, Federico, Bulyk, Martha L., Serrano, Luis, Stricher, François
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995082/
https://www.ncbi.nlm.nih.gov/pubmed/20685816
http://dx.doi.org/10.1093/nar/gkq683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995082/
https://www.ncbi.nlm.nih.gov/pubmed/20685816
http://dx.doi.org/10.1093/nar/gkq683

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