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Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example
Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations have real effects in the protein’s function is not trivial. Protein design tools are commonly used to explain mutations that affect protein sta...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995082/ https://www.ncbi.nlm.nih.gov/pubmed/20685816 http://dx.doi.org/10.1093/nar/gkq683 |