Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson’s disease. It has been found to work in the same pathway as the E3 ligase Parkin in the maintenance of flight muscles and dopaminergic neurons in Drosophila melanogaster and to recruit cytosolic Parkin to mitochondria to med...

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Detalles Bibliográficos
Autores principales: Jin, Seok Min, Lazarou, Michael, Wang, Chunxin, Kane, Lesley A., Narendra, Derek P., Youle, Richard J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995166/
https://www.ncbi.nlm.nih.gov/pubmed/21115803
http://dx.doi.org/10.1083/jcb.201008084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995166/
https://www.ncbi.nlm.nih.gov/pubmed/21115803
http://dx.doi.org/10.1083/jcb.201008084

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