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The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells

Neuronal gap junctional hemichannels, composed of pannexin-1 subunits, have been suggested to play a crucial role in epilepsy and brain ischaemia. After a few minutes of anoxia or ischaemia, neurons in brain slices show a rapid depolarization to ∼−20 mV, called the anoxic depolarization. Glutamate r...

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Detalles Bibliográficos
Autores principales: Madry, Christian, Haglerød, Camilla, Attwell, David
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995884/
https://www.ncbi.nlm.nih.gov/pubmed/20940167
http://dx.doi.org/10.1093/brain/awq284