A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

BACKGROUND: Down's syndrome (DS) is the most common genetic cause of mental retardation. Reduced number and aberrant architecture of dendritic spines are common features of DS neuropathology. However, the mechanisms involved in DS spine alterations are not known. In addition to a relevant role...

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Detalles Bibliográficos
Autores principales: Garcia, Octavio, Torres, Maria, Helguera, Pablo, Coskun, Pinar, Busciglio, Jorge
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996288/
https://www.ncbi.nlm.nih.gov/pubmed/21152035
http://dx.doi.org/10.1371/journal.pone.0014200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996288/
https://www.ncbi.nlm.nih.gov/pubmed/21152035
http://dx.doi.org/10.1371/journal.pone.0014200

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