PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation

BACKGROUND: Numerous studies have reported that increased expression of S100B, an intracellular Ca(2+ )receptor protein and secreted neuropeptide, exacerbates Alzheimer's disease (AD) pathology. However, the ability of S100B inhibitors to prevent/reverse AD histopathology remains controversial....

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Detalles Bibliográficos
Autores principales: Roltsch, Emily, Holcomb, Leigh, Young, Keith A, Marks, Alexander, Zimmer, Danna B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996465/
https://www.ncbi.nlm.nih.gov/pubmed/21080947
http://dx.doi.org/10.1186/1742-2094-7-78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996465/
https://www.ncbi.nlm.nih.gov/pubmed/21080947
http://dx.doi.org/10.1186/1742-2094-7-78

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