U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

In higher eukaryotes, U1 snRNP forms spliceosomes in equal stoichiometry with U2, U4, U5 and U6, however its abundance far exceeds that of the other snRNPs. Here, we used antisense morpholino oligonucleotide (AMO) to U1 snRNA for functional U1 snRNP knockdown in HeLa cells and identified accumulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaida, Daisuke, Berg, Michael G., Younis, Ihab, Kasim, Mumtaz, Singh, Larry N., Wan, Lili, Dreyfuss, Gideon
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996489/
https://www.ncbi.nlm.nih.gov/pubmed/20881964
http://dx.doi.org/10.1038/nature09479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996489/
https://www.ncbi.nlm.nih.gov/pubmed/20881964
http://dx.doi.org/10.1038/nature09479

Ejemplares similares