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Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis

BACKGROUND: RNA inhibition by siRNAs is a frequently used approach to identify genes required for specific biological processes. However RNAi screening using siRNAs is hampered by non-specific or off target effects of the siRNAs, making it difficult to separate genuine hits from false positives. It...

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Detalles Bibliográficos
Autores principales:	Sudbery, Ian, Enright, Anton J, Fraser, Andrew G, Dunham, Ian
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996961/ https://www.ncbi.nlm.nih.gov/pubmed/20230625 http://dx.doi.org/10.1186/1471-2164-11-175

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