TLR4 Inhibits Mesenchymal Stem Cell (MSC) STAT3 Activation and Thereby Exerts Deleterious Effects on MSC–Mediated Cardioprotection

BACKGROUND: Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors. Toll-like receptor 4 (TLR4) is expressed by MSC and induc...

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Detalles Bibliográficos
Autores principales: Wang, Yue, Abarbanell, Aaron M., Herrmann, Jeremy L., Weil, Brent R., Manukyan, Mariuxi C., Poynter, Jeffrey A., Meldrum, Daniel R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997048/
https://www.ncbi.nlm.nih.gov/pubmed/21151968
http://dx.doi.org/10.1371/journal.pone.0014206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997048/
https://www.ncbi.nlm.nih.gov/pubmed/21151968
http://dx.doi.org/10.1371/journal.pone.0014206

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