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TLR4 Inhibits Mesenchymal Stem Cell (MSC) STAT3 Activation and Thereby Exerts Deleterious Effects on MSC–Mediated Cardioprotection
BACKGROUND: Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors. Toll-like receptor 4 (TLR4) is expressed by MSC and induc...
Autores principales: | Wang, Yue, Abarbanell, Aaron M., Herrmann, Jeremy L., Weil, Brent R., Manukyan, Mariuxi C., Poynter, Jeffrey A., Meldrum, Daniel R. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997048/ https://www.ncbi.nlm.nih.gov/pubmed/21151968 http://dx.doi.org/10.1371/journal.pone.0014206 |
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