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Acetazolamide-based fungal chitinase inhibitors

Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be important for fungal cell wall remodelling, and inhibition of these enzymes has been proposed as a potential strategy for development of novel anti-fungals. The fungal pathogen Aspergillus fumigatus pos...

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Detalles Bibliográficos
Autores principales: Schüttelkopf, Alexander W., Gros, Ludovic, Blair, David E., Frearson, Julie A., van Aalten, Daan M.F., Gilbert, Ian H.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997425/
https://www.ncbi.nlm.nih.gov/pubmed/21044846
http://dx.doi.org/10.1016/j.bmc.2010.09.062