TRAIL treatment provokes mutations in surviving cells

Chemotherapy and radiotherapy commonly damage DNA and trigger p53-dependent apoptosis through intrinsic apoptotic pathways. Two unfortunate consequences of this mechanism are resistance due to blockade of p53 or intrinsic apoptosis pathways, and mutagenesis of non-malignant surviving cells which can...

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Detalles Bibliográficos
Autores principales: Lovric, M M, Hawkins, C J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997681/
https://www.ncbi.nlm.nih.gov/pubmed/20639907
http://dx.doi.org/10.1038/onc.2010.242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997681/
https://www.ncbi.nlm.nih.gov/pubmed/20639907
http://dx.doi.org/10.1038/onc.2010.242

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