Cargando…
A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na(+) Channel
Voltage-gated ion channels are transmembrane proteins that undergo complex conformational changes during their gating transitions. Both functional and structural data from K(+) channels suggest that extracellular and intracellular parts of the pore communicate with each other via a trajectory of int...
Autores principales: | Zarrabi, Touran, Cervenka, Rene, Sandtner, Walter, Lukacs, Peter, Koenig, Xaver, Hilber, Karlheinz, Mille, Markus, Lipkind, Gregory M., Fozzard, Harry A., Todt, Hannes |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998134/ https://www.ncbi.nlm.nih.gov/pubmed/20926383 http://dx.doi.org/10.1074/jbc.M110.132886 |
Ejemplares similares
-
A molecular switch between the outer and the inner vestibules of the voltage-gated Na(+) channel
por: Cervenka, René, et al.
Publicado: (2010) -
The Outer Vestibule of the Na(+) Channel–Toxin Receptor and Modulator of Permeation as Well as Gating
por: Cervenka, René, et al.
Publicado: (2010) -
Double mutant gating perturbation analysis predicts a high conformational stability of the domain IV S6 segment of the voltage-gated Na(+ )channel
por: Cervenka, René, et al.
Publicado: (2009) -
Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na(+) channels: mechanistic insights from recent crystal structures
por: Cervenka, Rene, et al.
Publicado: (2018) -
Second-hit kinetic perturbations reveal structural features of the domain IV S6 segment associated with fast inactivation
por: Cervenka, René, et al.
Publicado: (2008)