Crystal Structure of Leishmania major Oligopeptidase B Gives Insight into the Enzymatic Properties of a Trypanosomatid Virulence Factor

Oligopeptidase B (OPB) is a serine peptidase with dibasic substrate specificity. It is found in bacteria, plants, and trypanosomatid pathogens, where it has been identified as a virulence factor and potential drug target. In this study we expressed active recombinant Leishmania major OPB and provide...

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Detalles Bibliográficos
Autores principales: McLuskey, Karen, Paterson, Neil G., Bland, Nicholas D., Isaacs, Neil W., Mottram, Jeremy C.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998157/
https://www.ncbi.nlm.nih.gov/pubmed/20926390
http://dx.doi.org/10.1074/jbc.M110.156679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998157/
https://www.ncbi.nlm.nih.gov/pubmed/20926390
http://dx.doi.org/10.1074/jbc.M110.156679

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