Cargando…

Crystal Structure of Leishmania major Oligopeptidase B Gives Insight into the Enzymatic Properties of a Trypanosomatid Virulence Factor

Oligopeptidase B (OPB) is a serine peptidase with dibasic substrate specificity. It is found in bacteria, plants, and trypanosomatid pathogens, where it has been identified as a virulence factor and potential drug target. In this study we expressed active recombinant Leishmania major OPB and provide...

Descripción completa

Detalles Bibliográficos
Autores principales:	McLuskey, Karen, Paterson, Neil G., Bland, Nicholas D., Isaacs, Neil W., Mottram, Jeremy C.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998157/ https://www.ncbi.nlm.nih.gov/pubmed/20926390 http://dx.doi.org/10.1074/jbc.M110.156679

Ejemplares similares

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle
por: Cao, Zhenbo, et al.
Publicado: (2011)

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces
por: Moore, Benjamin, et al.
Publicado: (2011)

Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
por: Liu, Qun, et al.
Publicado: (2009)

Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)
por: Oosterheert, Wout, et al.
Publicado: (2020)

Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain
por: Peng, Guiqing, et al.
Publicado: (2012)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain
por: Carafoli, Federico, et al.
Publicado: (2009)

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
por: Gelinas, Amy D., et al.
Publicado: (2014)

Lack of an Efficient Endoplasmic Reticulum-localized Recycling System Protects Peroxiredoxin IV from Hyperoxidation
por: Cao, Zhenbo, et al.
Publicado: (2014)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Crystal Structure of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Fusion Core
por: Xu, Yanhui, et al.
Publicado: (2004)

Protein secondary structure determines the temporal relationship between folding and disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2020)

Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
por: Rodriguez, Fernanda, et al.
Publicado: (2014)

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
por: Underwood, Christina Rye, et al.
Publicado: (2010)

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
por: Akerboom, Jasper, et al.
Publicado: (2009)

Crystal Structure and Molecular Imaging of the Na(v) Channel β3 Subunit Indicates a Trimeric Assembly
por: Namadurai, Sivakumar, et al.
Publicado: (2014)

Crystal Structure of Arabidopsis Deg2 Protein Reveals an Internal PDZ Ligand Locking the Hexameric Resting State
por: Sun, Renhua, et al.
Publicado: (2012)

Crystal structure of the first eukaryotic bilin reductase GtPEBB reveals a flipped binding mode of dihydrobiliverdin
por: Sommerkamp, Johannes A., et al.
Publicado: (2019)

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2017)

Crystal Structure of Staphylococcus aureus Metallopeptidase (Sapep) Reveals Large Domain Motions between the Manganese-bound and Apo-states
por: Girish, Tavarekere S., et al.
Publicado: (2010)

Structural Basis for Coronavirus-mediated Membrane Fusion: CRYSTAL STRUCTURE OF MOUSE HEPATITIS VIRUS SPIKE PROTEIN FUSION CORE
por: Xu, Yanhui, et al.
Publicado: (2004)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
por: Guhaniyogi, Jayita, et al.
Publicado: (2009)

Crystal Structure of SmcR, a Quorum-sensing Master Regulator of Vibrio vulnificus, Provides Insight into Its Regulation of Transcription
por: Kim, Yoonjeong, et al.
Publicado: (2010)

Crystal Structure and Biophysical Properties of Bacillus subtilis BdbD: AN OXIDIZING THIOL:DISULFIDE OXIDOREDUCTASE CONTAINING A NOVEL METAL SITE
por: Crow, Allister, et al.
Publicado: (2009)

Crystal Structure of the Human N-Myc Downstream-regulated Gene 2 Protein Provides Insight into Its Role as a Tumor Suppressor
por: Hwang, Jungwon, et al.
Publicado: (2011)

Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY
por: Hong, Bum Soo, et al.
Publicado: (2010)

Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME
por: Bacik, John-Paul, et al.
Publicado: (2010)

Crystal Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Dimerization Domain Reveals Evolutionary Linkage between Corona- and Arteriviridae
por: Yu, I-Mei, et al.
Publicado: (2006)

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407
por: Anthony, Colin S., et al.
Publicado: (2010)

Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES
por: Cho, Chao-Cheng, et al.
Publicado: (2016)

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function
por: Franco-Echevarría, Elsa, et al.
Publicado: (2017)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

The Structure of an Interdomain Complex That Regulates Talin Activity
por: Goult, Benjamin T., et al.
Publicado: (2009)

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
por: Goult, Benjamin T., et al.
Publicado: (2013)

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β(2)-Microglobulin
por: Halabelian, Levon, et al.
Publicado: (2014)

The B-type Channel Is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritin
por: Wong, Steve G., et al.
Publicado: (2015)

Structural Determinants of Integrin Binding to the Talin Rod
por: Gingras, Alexandre R., et al.
Publicado: (2009)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_99h9johtgspq3m38lg8pqd5784