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The Second-Shell Metal Ligands of Human Arginase Affect Coordination of the Nucleophile and Substrate

[Image: see text] The active sites of eukaryotic arginase enzymes are strictly conserved, especially the first- and second-shell ligands that coordinate the two divalent metal cations that generate a hydroxide molecule for nucleophilic attack on the guanidinium carbon of l-arginine and the subsequen...

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Detalles Bibliográficos
Autores principales: Stone, Everett M., Chantranupong, Lynne, Georgiou, George
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998210/
https://www.ncbi.nlm.nih.gov/pubmed/21053939
http://dx.doi.org/10.1021/bi101542t