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The Second-Shell Metal Ligands of Human Arginase Affect Coordination of the Nucleophile and Substrate
[Image: see text] The active sites of eukaryotic arginase enzymes are strictly conserved, especially the first- and second-shell ligands that coordinate the two divalent metal cations that generate a hydroxide molecule for nucleophilic attack on the guanidinium carbon of l-arginine and the subsequen...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998210/ https://www.ncbi.nlm.nih.gov/pubmed/21053939 http://dx.doi.org/10.1021/bi101542t |