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Direct Injection of Functional Single-Domain Antibodies from E. coli into Human Cells

Intracellular proteins have a great potential as targets for therapeutic antibodies (Abs) but the plasma membrane prevents access to these antigens. Ab fragments and IgGs are selected and engineered in E. coli and this microorganism may be also an ideal vector for their intracellular delivery. In th...

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Detalles Bibliográficos
Autores principales: Blanco-Toribio, Ana, Muyldermans, Serge, Frankel, Gad, Fernández, Luis Ángel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999559/
https://www.ncbi.nlm.nih.gov/pubmed/21170340
http://dx.doi.org/10.1371/journal.pone.0015227