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Direct Injection of Functional Single-Domain Antibodies from E. coli into Human Cells
Intracellular proteins have a great potential as targets for therapeutic antibodies (Abs) but the plasma membrane prevents access to these antigens. Ab fragments and IgGs are selected and engineered in E. coli and this microorganism may be also an ideal vector for their intracellular delivery. In th...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999559/ https://www.ncbi.nlm.nih.gov/pubmed/21170340 http://dx.doi.org/10.1371/journal.pone.0015227 |