Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors

Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that mutational escape in three HLA-A11-, B8- and B7- restricted immunodominant HIV-1 C...

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Detalles Bibliográficos
Autores principales: Yang, Yue, Huang, Jinghe, Toth, Ildiko, Lichterfeld, Mathias, Yu, Xu G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999561/
https://www.ncbi.nlm.nih.gov/pubmed/21170342
http://dx.doi.org/10.1371/journal.pone.0015084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999561/
https://www.ncbi.nlm.nih.gov/pubmed/21170342
http://dx.doi.org/10.1371/journal.pone.0015084

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