Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca(2+) ([Ca(2+)]cyto) through a phospholipase C-independent pathway, which is required for virus...

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Detalles Bibliográficos
Autores principales: Hyser, Joseph M., Collinson-Pautz, Matthew R., Utama, Budi, Estes, Mary K.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999940/
https://www.ncbi.nlm.nih.gov/pubmed/21151776
http://dx.doi.org/10.1128/mBio.00265-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999940/
https://www.ncbi.nlm.nih.gov/pubmed/21151776
http://dx.doi.org/10.1128/mBio.00265-10

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