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Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca(2+) ([Ca(2+)]cyto) through a phospholipase C-independent pathway, which is required for virus...

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Detalles Bibliográficos
Autores principales:	Hyser, Joseph M., Collinson-Pautz, Matthew R., Utama, Budi, Estes, Mary K.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999940/ https://www.ncbi.nlm.nih.gov/pubmed/21151776 http://dx.doi.org/10.1128/mBio.00265-10

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