Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Exhibit Enhanced NGF-Stimulated Signaling

Missense mutants in the late endosomal Rab7 GTPase cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B). As yet, the pathological mechanisms connecting mutant Rab7 protein expression to altered neuronal function are undefined. Here, we analyze the effects Ra...

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Detalles Bibliográficos
Autores principales: BasuRay, Soumik, Mukherjee, Sanchita, Romero, Elsa, Wilson, Michael C., Wandinger-Ness, Angela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000344/
https://www.ncbi.nlm.nih.gov/pubmed/21151572
http://dx.doi.org/10.1371/journal.pone.0015351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000344/
https://www.ncbi.nlm.nih.gov/pubmed/21151572
http://dx.doi.org/10.1371/journal.pone.0015351

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