Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Exhibit Enhanced NGF-Stimulated Signaling

Missense mutants in the late endosomal Rab7 GTPase cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B). As yet, the pathological mechanisms connecting mutant Rab7 protein expression to altered neuronal function are undefined. Here, we analyze the effects Ra...

Descripción completa

Detalles Bibliográficos
Autores principales: BasuRay, Soumik, Mukherjee, Sanchita, Romero, Elsa, Wilson, Michael C., Wandinger-Ness, Angela
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000344/
https://www.ncbi.nlm.nih.gov/pubmed/21151572
http://dx.doi.org/10.1371/journal.pone.0015351

Ejemplares similares

Ejemplares similares