Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogaster

Mutations in PINK1 and Parkin cause familial, early onset Parkinson's disease. In Drosophila melanogaster, PINK1 and Parkin mutants show similar phenotypes, such as swollen and dysfunctional mitochondria, muscle degeneration, energy depletion, and dopaminergic (DA) neuron loss. We previously sh...

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Detalles Bibliográficos
Autores principales: Liu, Song, Lu, Bingwei
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000346/
https://www.ncbi.nlm.nih.gov/pubmed/21151574
http://dx.doi.org/10.1371/journal.pgen.1001237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000346/
https://www.ncbi.nlm.nih.gov/pubmed/21151574
http://dx.doi.org/10.1371/journal.pgen.1001237

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