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Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant
Mitochondrial dysfunction is characteristic of many neurodegenerative diseases. The Parkinson's disease-associated ubiquitin–protein ligase, Parkin, is important in the elimination of damaged mitochondria by autophagy (mitophagy) in a multistep process. Here, we show that a Parkin RING domain m...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000674/ https://www.ncbi.nlm.nih.gov/pubmed/20889486 http://dx.doi.org/10.1093/hmg/ddq428 |