Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53

Somatic and germline mutations in PTEN (phosphatase and tensin homolog deleted on chromosome 10) are found in sporadic cancers and Cowden syndrome patients, respectively. Recent identification of naturally occurring cancer and germline mutations within the ATP-binding motifs of PTEN (heretofore refe...

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Detalles Bibliográficos
Autores principales: He, Xin, Ni, Ying, Wang, Yu, Romigh, Todd, Eng, Charis
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000677/
https://www.ncbi.nlm.nih.gov/pubmed/20926450
http://dx.doi.org/10.1093/hmg/ddq434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000677/
https://www.ncbi.nlm.nih.gov/pubmed/20926450
http://dx.doi.org/10.1093/hmg/ddq434

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