Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes produced by the treatment of biological systems wit...

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Detalles Bibliográficos
Autores principales: Baum, Patrick, Schmid, Ramona, Ittrich, Carina, Rust, Werner, Fundel-Clemens, Katrin, Siewert, Susanne, Baur, Martin, Mara, Lisa, Gruenbaum, Lore, Heckel, Armin, Eils, Roland, Kontermann, Roland E., Roth, Gerald J., Gantner, Florian, Schnapp, Andreas, Park, John E., Weith, Andreas, Quast, Karsten, Mennerich, Detlev
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000806/
https://www.ncbi.nlm.nih.gov/pubmed/21170314
http://dx.doi.org/10.1371/journal.pone.0014272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000806/
https://www.ncbi.nlm.nih.gov/pubmed/21170314
http://dx.doi.org/10.1371/journal.pone.0014272

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