Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

BACKGROUND: Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prosta...

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Detalles Bibliográficos
Autores principales: Dai, Yao, DeSano, Jeffrey, Tang, Wenhua, Meng, Xiaojie, Meng, Yang, Burstein, Ezra, Lawrence, Theodore S., Xu, Liang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000808/
https://www.ncbi.nlm.nih.gov/pubmed/21170316
http://dx.doi.org/10.1371/journal.pone.0014153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000808/
https://www.ncbi.nlm.nih.gov/pubmed/21170316
http://dx.doi.org/10.1371/journal.pone.0014153

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