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MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy
Zinc plays a crucial role in the biology of p53 in that p53 binds to DNA through a structurally complex domain stabilized by zinc atom. The p53 negative regulator MDM2 protein also carries a C-terminal RING domain that coordinates two zinc atoms which are responsible for p53 nuclear export and prote...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000878/ https://www.ncbi.nlm.nih.gov/pubmed/20818437 http://dx.doi.org/10.1038/onc.2010.403 |