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MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy

Zinc plays a crucial role in the biology of p53 in that p53 binds to DNA through a structurally complex domain stabilized by zinc atom. The p53 negative regulator MDM2 protein also carries a C-terminal RING domain that coordinates two zinc atoms which are responsible for p53 nuclear export and prote...

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Detalles Bibliográficos
Autores principales:	Azmi, Asfar S., Philip, Philip A., Beck, Frances W.J., Wang, Zhiwei, Banerjee, Sanjeev, Wang, Shaomeng, Yang, Dajun, Sarkar, Fazlul H., Mohammad, Ramzi M.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000878/ https://www.ncbi.nlm.nih.gov/pubmed/20818437 http://dx.doi.org/10.1038/onc.2010.403

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