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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR a...

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Detalles Bibliográficos
Autores principales: Heid, Iris M., Jackson, Anne U., Randall, Joshua C., Winkler, Thomas W., Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M. Carola, Speliotes, Elizabeth K., Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C., Bouatia-Naji, Nabila, Harris, Tamara B., Berndt, Sonja I., Ingelsson, Erik, Willer, Cristen J., Weedon, Michael N., Luan, Jian'an, Vedantam, Sailaja, Esko, Tõnu, Kilpeläinen, Tuomas O., Kutalik, Zoltán, Li, Shengxu, Monda, Keri L., Dixon, Anna L., Holmes, Christopher C., Kaplan, Lee M., Liang, Liming, Min, Josine L., Moffatt, Miriam F., Molony, Cliona, Nicholson, George, Schadt, Eric E., Zondervan, Krina T., Feitosa, Mary F., Ferreira, Teresa, Allen, Hana Lango, Weyant, Robert J., Wheeler, Eleanor, Wood, Andrew R., Estrada, Karol, Goddard, Michael E., Lettre, Guillaume, Mangino, Massimo, Nyholt, Dale R., Purcell, Shaun, Vernon Smith, Albert, Visscher, Peter M., Yang, Jian, McCaroll, Steven A., Nemesh, James, Voight, Benjamin F., Absher, Devin, Amin, Najaf, Aspelund, Thor, Coin, Lachlan, Glazer, Nicole L., Hayward, Caroline, Heard-Costa, Nancy L., Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kapur, Karen, Ketkar, Shamika, Knowles, Joshua W., Kraft, Peter, Kraja, Aldi T., Lamina, Claudia, Leitzmann, Michael F., McKnight, Barbara, Morris, Andrew P., Ong, Ken K., Perry, John R.B., Peters, Marjolein J., Polasek, Ozren, Prokopenko, Inga, Rayner, Nigel W., Ripatti, Samuli, Rivadeneira, Fernando, Robertson, Neil R., Sanna, Serena, Sovio, Ulla, Surakka, Ida, Teumer, Alexander, van Wingerden, Sophie, Vitart, Veronique, Zhao, Jing Hua, Cavalcanti-Proença, Christine, Chines, Peter S., Fisher, Eva, Kulzer, Jennifer R., Lecoeur, Cecile, Narisu, Narisu, Sandholt, Camilla, Scott, Laura J., Silander, Kaisa, Stark, Klaus, Tammesoo, Mari-Liis, Teslovich, Tanya M., John Timpson, Nicholas, Watanabe, Richard M., Welch, Ryan, Chasman, Daniel I., Cooper, Matthew N., Jansson, John-Olov, Kettunen, Johannes, Lawrence, Robert W., Pellikka, Niina, Perola, Markus, Vandenput, Liesbeth, Alavere, Helene, Almgren, Peter, Atwood, Larry D., Bennett, Amanda J., Biffar, Reiner, Bonnycastle, Lori L., Bornstein, Stefan R., Buchanan, Thomas A., Campbell, Harry, Day, Ian N.M., Dei, Mariano, Dörr, Marcus, Elliott, Paul, Erdos, Michael R., Eriksson, Johan G., Freimer, Nelson B., Fu, Mao, Gaget, Stefan, Geus, Eco J.C., Gjesing, Anette P., Grallert, Harald, Gräßler, Jürgen, Groves, Christopher J., Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Havulinna, Aki S., Herzig, Karl-Heinz, Hicks, Andrew A., Hui, Jennie, Igl, Wilmar, Jousilahti, Pekka, Jula, Antti, Kajantie, Eero, Kinnunen, Leena, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Kroemer, Heyo K., Krzelj, Vjekoslav, Kuusisto, Johanna, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lathrop, G. Mark, Lokki, Marja-Liisa, Luben, Robert N., Ludwig, Barbara, McArdle, Wendy L., McCarthy, Anne, Morken, Mario A., Nelis, Mari, Neville, Matt J., Paré, Guillaume, Parker, Alex N., Peden, John F., Pichler, Irene, Pietiläinen, Kirsi H., Platou, Carl G.P., Pouta, Anneli, Ridderstråle, Martin, Samani, Nilesh J., Saramies, Jouko, Sinisalo, Juha, Smit, Jan H., Strawbridge, Rona J., Stringham, Heather M., Swift, Amy J., Teder-Laving, Maris, Thomson, Brian, Usala, Gianluca, van Meurs, Joyce B.J., van Ommen, Gert-Jan, Vatin, Vincent, Volpato, Claudia B., Wallaschofski, Henri, Walters, G. Bragi, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Witte, Daniel R., Zgaga, Lina, Zitting, Paavo, Beilby, John P., James, Alan L., Kähönen, Mika, Lehtimäki, Terho, Nieminen, Markku S., Ohlsson, Claes, Palmer, Lyle J., Raitakari, Olli, Ridker, Paul M., Stumvoll, Michael, Tönjes, Anke, Viikari, Jorma, Balkau, Beverley, Ben-Shlomo, Yoav, Bergman, Richard N., Boeing, Heiner, Smith, George Davey, Ebrahim, Shah, Froguel, Philippe, Hansen, Torben, Hengstenberg, Christian, Hveem, Kristian, Isomaa, Bo, Jørgensen, Torben, Karpe, Fredrik, Khaw, Kay-Tee, Laakso, Markku, Lawlor, Debbie A., Marre, Michel, Meitinger, Thomas, Metspalu, Andres, Midthjell, Kristian, Pedersen, Oluf, Salomaa, Veikko, Schwarz, Peter E.H., Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T., Wareham, Nicholas J., Arnold, Alice M., Beckmann, Jacques S., Bergmann, Sven, Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Collins, Francis S., Eiriksdottir, Gudny, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Hattersley, Andrew T., Hofman, Albert, Hu, Frank B., Illig, Thomas, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Kao, W.H. Linda, Kaprio, Jaakko, Launer, Lenore J., Munroe, Patricia B., Oostra, Ben, Penninx, Brenda W., Pramstaller, Peter P., Psaty, Bruce M., Quertermous, Thomas, Rissanen, Aila, Rudan, Igor, Shuldiner, Alan R., Soranzo, Nicole, Spector, Timothy D., Syvanen, Ann-Christine, Uda, Manuela, Uitterlinden, André, Völzke, Henry, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Wright, Alan F., Abecasis, Gonçalo R., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Groop, Leif C., Haritunians, Talin, Hunter, David J., Kaplan, Robert C., North, Kari E., O'Connell, Jeffrey R., Peltonen, Leena, Schlessinger, David, Strachan, David P., Hirschhorn, Joel N., Assimes, Themistocles L., Wichmann, H.-Erich, Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Stefansson, Kari, Cupples, L. Adrienne, Loos, Ruth J.F., Barroso, Inês, McCarthy, Mark I., Fox, Caroline S., Mohlke, Karen L., Lindgren, Cecilia M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924/
https://www.ncbi.nlm.nih.gov/pubmed/20935629
http://dx.doi.org/10.1038/ng.685