Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo

Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects on client protein degradation and cancer cell growth inhibition has not been thoro...

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Detalles Bibliográficos
Autores principales: Tillotson, Bonnie, Slocum, Kelly, Coco, John, Whitebread, Nigel, Thomas, Brian, West, Kip A., MacDougall, John, Ge, Jie, Ali, Janid A., Palombella, Vito J., Normant, Emmanuel, Adams, Julian, Fritz, Christian C.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000965/
https://www.ncbi.nlm.nih.gov/pubmed/20940293
http://dx.doi.org/10.1074/jbc.M110.141580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000965/
https://www.ncbi.nlm.nih.gov/pubmed/20940293
http://dx.doi.org/10.1074/jbc.M110.141580

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