Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions

A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice. The mech...

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Detalles Bibliográficos
Autores principales: Deng, Wenhan, Garrett, Caroline, Dombert, Benjamin, Soura, Violetta, Banks, Gareth, Fisher, Elizabeth M. C., van der Brug, Marcel P., Hafezparast, Majid
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000974/
https://www.ncbi.nlm.nih.gov/pubmed/20889981
http://dx.doi.org/10.1074/jbc.M110.178087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000974/
https://www.ncbi.nlm.nih.gov/pubmed/20889981
http://dx.doi.org/10.1074/jbc.M110.178087

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